Welcome to our research webpages

We are a research group based in the Department of Chemistry at the University of Oxford. We are interested in the biophysical basis of function, and malfunction, of proteins in health and disease.

We combine advanced mass spectrometry techniques with complementary technologies to study the structure and dynamics of macromolecules, and relate this to their behaviour in the cell.

Of particular interest to us are “molecular chaperones”, and how these interact with destabilised target proteins to prevent their aggregation and deposition that might otherwise lead to a variety of maladies.

We are very grateful for the support for our research by the Royal Society, EPSRC, BBSRC, MRC, British Heart Foundation, Wellcome Trust, and John Fell Fund.

From mass spectrometry to protein function